Biopharmaceutics MCQs | Part-1

Biopharmaceutics MCQs (Part-1)

This free quiz test on biopharmaceutics will help you to prepare for competitive exams or interviews.

1 / 25

Which of the following is not a mechanism for pharmacokinetic analysis?

Compartment analysis

Non compartment analysis

Physiologic modeling

Human model

2 / 25

Which one of the following bonds is not generally a bond through which a drug will bind in our body?

Hydrogen bond

Hydrophobic bond

Ionic bond

Covalent bond

3 / 25

What is the perfusion rate?

The total volume of blood

The volume of blood that flows through the heart per unit time

The volume of blood that flows per unit time per unit volume of tissue

The volume of tissue that flows per unit time per unit area of a blood vessel

4 / 25

The body water has 3 distinct compartments. Which one of these is not one of the compartments?

Vascular fluid

Intracellular fluid

Extracellular fluid

Between the tissue layers

5 / 25

Who has poorly developed BBB?

Infants

Adults Of age more than 20

Aged

Children at puberty

6 / 25

Which drugs get absorbed in the stomach mostly?

Basic drugs

Acidic Drugs

Neutral drugs

No drug gets absorbed in the stomach

7 / 25

The entire length of the GI is lined by:

Blood vessels

Nerves

Mucopolysaccharides

No lining direct contact with the cell

8 / 25

Which of the following will be the slowest step in tablet drug absorption?

Tablet disintegration to granules

Granules disintegration to fine particles

Fine particles dissolution

Dissolution absorbed into the blood

9 / 25

According to the pH-partition theory which form of the drug gets absorbed mostly?

Hydrated form

Aggregated form

Ionised

Unionised

10 / 25

Which one of these options is not one of the limitations of pH-partition theory?

Presence if virtual membrane pH

Absorption of ionized drugs

Influence of GI surface area

Dissolution rate

11 / 25

Which of the following equations correct for Henderson-Hasselbach equation for weak acids?

PH = pKa – log (Unionized drug concentration /Ionized drug concentration)

PH = pKa – log (Ionized drug concentration/ Unionized drug concentration)

PH = pKa + log (Ionized drug concentration/ Unionized drug concentration)

PH = pKa + log (Unionized drug concentration /Ionized drug concentration)

12 / 25

According to the pH-partition hypothesis which one of the given options doesn’t govern the absorption?

The molecular size of the drug

PH at the absorption site

Lipid solubility of unionized drugs

Dissociation constant

13 / 25

Which one of the following is a critical rate-limiting step of drug absorption?

Rate of drug disintegration

Size of the drug

Size of the porous particle

Rate of dissolution

14 / 25

Which kind of molecules cannot pass through a pore transport?

Low Molecular weight molecules

Water-soluble drugs

Molecules up to 400 Dalton

Molecules greater than 400 Dalton

15 / 25

What is the driving force for Passive Diffusion?

Concentration gradient only

Electrochemical gradient only

Charge equilibration and concentration gradient

Concentration and Electrochemical gradient both

16 / 25

Which is the major process of absorption for more than 90% of drugs?

Facilitated diffusion

Active transport

Endocytosis

Passive diffusion

17 / 25

Which part of the membrane is responsible for the relative impermeability of polar molecules in and out of the cell?

Polar head

Hydrophobic head

Hydrophobic core

Non polar head

18 / 25

Following are the Phase I reactions except:

Oxidative reactions

Reductive reaction

Hydrolytic reaction

Sulfation reaction

19 / 25

Identify the process where structurally same compounds compete for the same site on an enzyme to inhibit that:

Competitive inhibition

Repression

Non-competitive inhibition

Altered physiology

20 / 25

The kinetics of capacity-limited or saturable processes is best described by:

Michaelis Menten equation

Handerson Hasselbalch Equation

Hackle’s Equation

Noyes Whitney Equation

21 / 25

Induction of drug metabolism leads to__________ in half-life of drug.

Increase

Decrease

Remain constant

Unpredictable

22 / 25

Dose Dependent pharmacokinetics is also known as:

One compartment kinetics, when the dose is administered by IV bolus route

One compartment kinetics, when the dose is administered by IV infusion route

One compartment kinetics, when the dose is administered by oral route

Non-linear pharmacokinetics

23 / 25

While designing dosage regimen for narrow therapeutic index drug, the preferred method is:

small doses administered at frequent intervals

larger doses administered at relatively longer intervals

small doses administered at longer interval

administered twice a day

24 / 25

Mechanism of drug excretion through skin is:

Active secretion

Passive diffusion

Passive reabsorption

Glomerular secretion

25 / 25

One compartment IV infusion model follows:

Zero order absorption and first order elimination kinetics

First order absorption and first order elimination kinetics

Zero order absorption and Zero order elimination kinetics

First order absorption and Zero order elimination kinetics

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