Biopharmaceutics MCQs | Part-2

Biopharmaceutics MCQs (Part-2)

This free quiz test on biopharmaceutics will help you to prepare for competitive exams or interviews.

1 / 25

Capacity limited kinetics is also called as:

Linear Pharmacokinetics

Non linear pharmacokinetics

Dose dependent kinetics

First order Kinetics

2 / 25

Identify the kinetics- plasma drug concentration versus time plots are directly related to the
dose of the drug:

Linear pharmacokinetics

Non linear pharmacokinetics

Mixed order kinetics

Multiple kinetics

3 / 25

What is bioavailability?

The rate and extent of absorption of the unchanged drug from its dosage form

The time of absorption of the drug from its dosage form

The time of absorption of the unchanged drug from its dosage form

The rate of absorption of the drug from its dosage form

4 / 25

Surfactants are used as absorption enhancers at concentration:

above critical micelle concentration

below critical micelle concentration

critical micelle concentration does not affect

equal to critical micelle concentration

5 / 25

Which of the following is pharmacodynamics method of studying bioavailability:

Acute pharmacologic response

Plasma-level time studies

Urinary excretion studies

Stool excretion studies

6 / 25

Favourable pH range for absorption through small intestine is:

1 to 2.5

4 to 4.5

5 to 7.5

10- 12.5

7 / 25

Which organ can be the part of central compartment:

Muscle

Bones

Lungs

Adipose tissue

8 / 25

Non compartmental analysis model is based on:

Blood perfusion to the organ

Physiological organs

Drug diffusion to organ

Statistical moments theory

9 / 25

Select the equation that gives the rate of drug dissolution from a tablet:

Fick’s law

Handerson Hasselbatch equation

Noyes Whitney equation

Michelis Menten equation

10 / 25

Model independent approach is also termed as:

Non-compartmental approach

Compartment model

Physiological model

Distributed parameter model

11 / 25

Pharmacokinetics is study of kinetics of:

Method of new drug development

Pharmacological effect of drugs

Mechanism of drug action

Absorption, distribution, metabolism and excretion of drugs

12 / 25

Which of the following statements is true?

Rate of excretion = Rate of filtration - Rate of Secretion - Rate of reabsorption

Rate of excretion = Rate of filtration -Rate of Secretion + Rate of reabsorption

Rate of excretion = Rate of filtration +Rate of Secretion - Rate of reabsorption

Rate of excretion = Rate of filtration +Rate of Secretion + Rate of reabsorption

13 / 25

A Multicompartment model assumes all rate constants are:

Zero order

First order

Mixed order

Pseudo first order

14 / 25

Which of the following statement is true?

Drugs with high protein binding have apparently low volume of distribution

Drugs with low protein binding have apparently low volume of distribution

Drugs with high protein binding have apparently high volume of distribution

Drugs with low protein binding have apparently low volume of distribution

15 / 25

In catenary model, compartments are joined:

in series

in parallel

clustered

like planetary system

16 / 25

Interfacial barrier model is also known as:

Limited solvation theory

Danckwert model

Noyes–Whitney Relationship

Hixon–Crowell Cube Root Law

17 / 25

Nephron is functional unit of:

Liver

Lung

Heart

Kidney

18 / 25

The term used to denote that the drug substance in two or more identical dosage forms,
reaches the systemic circulation at the same relative rate and to the same relative extent is:

Pharmaceutical equivalence

Chemical Equivalence

Therapeutic Equivalence

Bioequivalence

19 / 25

The order of dissolution of different solid forms of drugs is:

Amorphous > Metastable >Stable

Amorphous > Stable > Metastable

Stable > Amorphous > Metastable

Metastable > Amorphous >Stable

20 / 25

Principal site of oral absorption is:

Small intestine

Stomach

Large intestine

Rectum

21 / 25

Bioavailability of drug can be calculated by using which parameter?

Total systemic clearance

Volume of distribution

Area Under the Curve

Absorption rate Constant

22 / 25

Renal Clearance is expressed as:

Rate of urinary excretion/ plasma drug concentration

Elimination rate/ Plasma drug concentration

Plasma drug concentration / Rate of urinary excretion

Plasma drug concentration / Elimination rate

23 / 25

In case of multiple IV injections, the ratio of steady state concentration to initial
concentration is called as:

Accumulation factor

Maxima

Minima

Absorption factor

24 / 25

Transfer of drug from plasma to tissue depends on:

Blood perfusion rate of tissue

Weight of tissue

Size of tissue

Gastric emptying rate

25 / 25

Apparent volume of distribution is:

Plasma drug concentration X amount of drug in body

Plasma drug concentration / amount of drug in body

Amount of drug in the body X plasma drug concentration

Amount of drug in the body /plasma drug concentration

Your score is

The average score is 54%

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