Frequently Asked Questions on USP Apparatus 1
Q. What is USP Apparatus 1?
USP Apparatus 1 refers to baskets, which were the first standardized apparatus added to the USP.
Q. How common is the use of baskets in dissolution testing?
Baskets are the second most common apparatus used in methods today due to their versatility for various dosage forms.
Q. When should baskets be considered for use in dissolution testing?
Baskets should be considered when:
- A product needs to be contained or suspended to prevent floating.
- Coning issues at the bottom of the vessel need to be avoided.
- Gentler mixing is required.
Q. How well do baskets mix compared to other USP apparatuses?
Baskets do not mix well compared to other USP apparatuses. Since rotating a cylinder does not create much mixing, proper basket condition is crucial to avoid variability in results.
Q. Why is it important to keep baskets in good condition?
Baskets should be kept in good condition (not bent, dented, etc.) because deformations can increase mixing and make results more variable.
Q. What role does the 3-clip attachment play in using baskets?
The 3-clip attachment is important because it helps secure the baskets on the shaft, ensuring consistent mixing.
Q. What is the standard mesh size for baskets in USP <711>?
The standard mesh size for baskets in USP <711> is 40-mesh.
Q. What options are available if a 40-mesh basket clogs?
More open baskets, such as 10-mesh and 20-mesh baskets, as well as slotted baskets, are available.
Q. What options are available if the product falls out of the basket?
Higher mesh baskets can be used to prevent the product from falling out.
Q. Are there different sizes of baskets available?
Yes, there are bolus baskets for larger dosage forms and mini baskets for smaller dosage forms.
Q. How should baskets be handled and cleaned?
- Baskets are fragile and should be handled with care.
- They should be removed and attached only by the top ring.
- Cleaning should be done by rinsing in the sink, followed by sonication in alcohol.
Q. How should baskets be stored when not in use?
Baskets should always be stored in a protected case when not in use.
Read also:
- Common Interview Questions and Answers on Analytical Development
- Pharmaceutical Quality Control Interview Questions and Answers
- Common Interview Questions and Answers on Stability Testing
- What is the Role of Antifoaming Agents in Dissolution Testing?
Resource Person: Vikas Bedi
